Prevalence of Elevated Lipoprotein(a) and its Association With Subclinical Atherosclerosis in 2.9 Million Chinese Adults (2025)

  • 1. Berg K. "A new serum type system in man—the Lp system". Acta Pathol Microbiol Scand . 1963;59:369-382.

    CrossrefMedlineGoogle Scholar
  • 2. Patel A.P., Wang M., Pirruccello J.P., et al. "Lp(a) (lipoprotein[a]) concentrations and incident atherosclerotic cardiovascular disease: new insights from a large national Biobank". Arterioscler Thromb Vasc Biol . 2021;41:1: 465-474.

    CrossrefMedlineGoogle Scholar
  • 3. Erqou S., Kaptoge S., Perry P.L., et al.Emerging Risk Factors Collaboration. "Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality". JAMA . 2009;302:4: 412-423.

    CrossrefMedlineGoogle Scholar
  • 4. Kamstrup P.R., Tybjaerg-Hansen A., Steffensen R., Nordestgaard B.G. "Genetically elevated lipoprotein(a) and increased risk of myocardial infarction". JAMA . 2009;301:22: 2331-2339.

    CrossrefMedlineGoogle Scholar
  • 5. Clarke R., Peden J.F., Hopewell J.C., et al. "Genetic variants associated with Lp(a) lipoprotein level and coronary disease". N Engl J Med . 2009;361:26: 2518-2528.

    CrossrefMedlineGoogle Scholar
  • 6. Varvel S., McConnell J.P., Tsimikas S. "Prevalence of elevated Lp(a) mass levels and patient thresholds in 532 359 patients in the United States". Arterioscler Thromb Vasc Biol . 2016;36:11: 2239-2245.

    CrossrefMedlineGoogle Scholar
  • 7. Duarte Lau F., Giugliano R.P. "Lipoprotein(a) and its significance in cardiovascular disease: a review". JAMA Cardiol . 2022;7:7: 760-769.

    CrossrefMedlineGoogle Scholar
  • 8. Libby P., Buring J.E., Badimon L., et al. "Atherosclerosis". Nat Rev Dis Primers . 2019;5:1: 56.

    CrossrefMedlineGoogle Scholar
  • 9. Willeit P., Tschiderer L., Allara E., et al. "Carotid intima-media thickness progression as surrogate marker for cardiovascular risk: meta-analysis of 119 clinical trials involving 100 667 patients". Circulation . 2020;142:7: 621-642.

    CrossrefMedlineGoogle Scholar
  • 10. Khan S.S., Post W.S., Guo X., et al. "Coronary artery calcium score and polygenic risk score for the prediction of coronary heart disease events". JAMA . 2023;329:20: 1768-1777.

    CrossrefMedlineGoogle Scholar
  • 11. Steffen B.T., Thanassoulis G., Duprez D., et al. "Race-based differences in lipoprotein(a)-associated risk of carotid atherosclerosis". Arterioscler Thromb Vasc Biol . 2019;39:3: 523-529.

    CrossrefMedlineGoogle Scholar
  • 12. Lin L., Deng K.Q., Chen Z., et al. "Lipoprotein(a) distribution and its association with carotid arteriopathy in the Chinese population". Atherosclerosis . 2023;372:1-9.

    CrossrefMedlineGoogle Scholar
  • 13. Duan Y., Zhao D., Sun J., et al. "Lipoprotein(a) is associated with the progression and vulnerability of new-onset carotid atherosclerotic plaque". Stroke . 2023;54:5: 1312-1319.

    CrossrefMedlineGoogle Scholar
  • 14. Martignoni F.V., Rl Junior J.E., Marques I.R., et al. "The association of lipoprotein(a) and coronary artery calcium in asymptomatic patients: a systematic review and meta-analysis". Eur J Prev Cardiol . 2024;31:6: 732-741.

    CrossrefMedlineGoogle Scholar
  • 15. Jackson C.L., Garg P.K., Guan W., et al. "Lipoprotein(a) and coronary artery calcium in comparison with other lipid biomarkers: the Multi-Ethnic Study of Atherosclerosis". J Clin Lipidol . 2023;17:4: 538-548.

    CrossrefMedlineGoogle Scholar
  • 16. China Health Culture Association-Medical and Health Credit Branch, China Cheng Xin International Credit Rating Co, Frost and Sullivan. "White paper: insight into trends in China's Health Management Services Industries China". 2021. Accessed March 6, 2025. http://www.ccx.com.cn/uploads/files/2022/0419/uybiaAKocvizUWkyJ12KnNtabX3zGvyqTxzx5rvo.pdf.

    Google Scholar
  • 17. Man S., Deng Y., Ma Y., et al. "Prevalence of liver steatosis and fibrosis in the general population and various high-risk populations: a nationwide study with 5.7 million adults in China". Gastroenterology . 2023;165:4: 1025-1040.

    CrossrefMedlineGoogle Scholar
  • 18. Kronenberg F., Mora S., Stroes E.S.G., et al. "Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement". Eur Heart J . 2022;43:39: 3925-3946.

    CrossrefMedlineGoogle Scholar
  • 19. Reyes-Soffer G., Ginsberg H.N., Berglund L., et al. "Lipoprotein(a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart Association". Arterioscler Thromb Vasc Biol . 2022;42:1: e48-e60.

    CrossrefMedlineGoogle Scholar
  • 20. Li J.J., Ma C.S., Zhao D., Yan X.W., Beijing Heart Society and Expert Committee. "Lipoprotein(a) and cardiovascular disease in Chinese population: A Beijing Heart Society expert scientific statement". JACC Asia . 2022;2:6: 653-665.

    View ArticleGoogle Scholar
  • 21. Koschinsky M.L., Bajaj A., Boffa M.B., et al. "A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice". J Clin Lipidol . 2024;18:3: e308-e319.

    CrossrefMedlineGoogle Scholar
  • 22. Zhu X., Cheng X., Zhong Y. "Establishment of reference interval of particle concentration for detecting lipoprotein(a) in Beijing". Lin Chuang Jian Yan Za Zhi . 2022;40:3: 204-208.

    Google Scholar
  • 23. Malick W.A., Goonewardena S.N., Koenig W., Rosenson R.S. "Clinical trial design for lipoprotein(a)-lowering therapies: JACC focus seminar 2/3". J Am Coll Cardiol . 2023;81:16: 1633-1645.

    View ArticleGoogle Scholar
  • 24. Stein J.H., Korcarz C.E., Hurst R.T., et al. "Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine". J Am Soc Echocardiogr . 2008;21:2: 93-111.quiz 89-90.

    CrossrefMedlineGoogle Scholar
  • 25. Wang X., Zhang R., Man S., et al. "Metabolic-associated fatty liver disease in relation to site-specific and multiple-site subclinical atherosclerosis". Liver Int . 2023;43:8: 1691-1698.

    CrossrefMedlineGoogle Scholar
  • 26. Chauhan G., Adams H.H.H., Satizabal C.L., et al. "Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting". Neurology . 2019;92:5: e486-e503.

    CrossrefMedlineGoogle Scholar
  • 27. Xu J., Liu J., Guo N., et al. "Performance of artificial intelligence-based coronary artery calcium scoring in non-gated chest CT". Eur J Radiol . 2021;145:110034.

    CrossrefGoogle Scholar
  • 28. Rumberger J.A., Brundage B.H., Rader D.J., Kondos G. "Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons". Mayo Clin Proc . 1999;74:3: 243-252.

    CrossrefMedlineGoogle Scholar
  • 29. Xia J., Guo C., Cao H., et al. "Impact of lipoprotein(a) level on cardiometabolic disease in the Chinese population: the CHCN-BTH Study". Eur J Clin Invest . 2022;52:2: e13689.

    CrossrefMedlineGoogle Scholar
  • 30. Vaverkova H., Karasek D., Halenka M., Cibickova L., Kubickova V. "Inverse association of lipoprotein (a) with markers of insulin resistance in dyslipidemic subjects". Physiol Res . 2017;66:Suppl 1: S113-S120.

    CrossrefMedlineGoogle Scholar
  • 31. Jung I., Kwon H., Park S.E., et al. "Serum lipoprotein(a) levels and insulin resistance have opposite effects on fatty liver disease". Atherosclerosis . 2020;308:1-5.

    CrossrefMedlineGoogle Scholar
  • 32. Reyes-Soffer G., Westerterp M. "Beyond lipoprotein(a) plasma measurements: lipoprotein(a) and inflammation". Pharmacol Res . 2021;169:105689.

    CrossrefMedlineGoogle Scholar
  • 33. Ritter M.M., Geiss H.C., Richter W.O., Schwandt P. "Lipoprotein(a) concentrations and phenotypes in controls and patients with hypercholesterolemia or hypertriglyceridemia". Metabolism . 1994;43:5: 572-578.

    CrossrefMedlineGoogle Scholar
  • 34. Larsson S.C., Wang L., Li X., Jiang F., Chen X., Mantzoros C.S. "Circulating lipoprotein(a) levels and health outcomes: Phenome-wide Mendelian randomization and disease-trajectory analyses". Metabolism . 2022;137:155347.

    CrossrefGoogle Scholar
  • 35. Randall O.S., Feseha H.B., Illoh K., et al. "Response of lipoprotein(a) levels to therapeutic life-style change in obese African-Americans". Atherosclerosis . 2004;172:1: 155-160.

    CrossrefMedlineGoogle Scholar
  • 36. Schmidt H., Wagner S., Kolm R., Manns M. "Lipoprotein(a) in cirrhosis". BMJ . 1992;304:6835: 1180.

    CrossrefMedlineGoogle Scholar
  • 37. Kronenberg F., Kuen E., Ritz E., et al. "Lipoprotein(a) serum concentrations and apolipoprotein(a) phenotypes in mild and moderate renal failure". J Am Soc Nephrol . 2000;11:1: 105-115.

    CrossrefMedlineGoogle Scholar
  • 38. Kronenberg F., Konig P., Neyer U., et al. "Multicenter study of lipoprotein(a) and apolipoprotein(a) phenotypes in patients with end-stage renal disease treated by hemodialysis or continuous ambulatory peritoneal dialysis". J Am Soc Nephrol . 1995;6:1: 110-120.

    CrossrefMedlineGoogle Scholar
  • 39. Fernandez-Friera L., Penalvo J.L., Fernandez-Ortiz A., et al. "Prevalence, vascular distribution, and multiterritorial extent of subclinical atherosclerosis in a middle-aged cohort: the PESA (Progression of Early Subclinical Atherosclerosis) Study". Circulation . 2015;131:24: 2104-2113.

    CrossrefMedlineGoogle Scholar
  • 40. Peng J., Liu M.M., Liu H.H., et al. "Lipoprotein (a)-mediated vascular calcification: population-based and in vitro studies". Metabolism . 2022;127:154960.

    CrossrefMedlineGoogle Scholar
  • 41. Guerra R., Yu Z., Marcovina S., Peshock R., Cohen J.C., Hobbs H.H. "Lipoprotein(a) and apolipoprotein(a) isoforms: no association with coronary artery calcification in the Dallas Heart Study". Circulation . 2005;111:12: 1471-1479.

    CrossrefMedlineGoogle Scholar
  • 42. Guan W., Cao J., Steffen B.T., et al. "Race is a key variable in assigning lipoprotein(a) cutoff values for coronary heart disease risk assessment: the Multi-Ethnic Study of Atherosclerosis". Arterioscler Thromb Vasc Biol . 2015;35:4: 996-1001.

    CrossrefMedlineGoogle Scholar
  • 43. Wang L., Zhou B., Zhao Z., et al. "Body-mass index and obesity in urban and rural China: findings from consecutive nationally representative surveys during 2004-18". Lancet . 2021;398:10294: 53-63.

    CrossrefMedlineGoogle Scholar
  • 44. Zhang M., Shi Y., Zhou B., et al. "Prevalence, awareness, treatment, and control of hypertension in China, 2004-18: findings from six rounds of a national survey". BMJ . 2023;380:e071952.

    Google Scholar
  • 45. Yang W., Lu J., Weng J., et al. "Prevalence of diabetes among men and women in China". N Engl J Med . 2010;362:12: 1090-1101.

    CrossrefMedlineGoogle Scholar
  • 46. Lu Y., Zhang H., Lu J., et al. "Prevalence of dyslipidemia and availability of lipid-lowering medications among primary health care settings in China". JAMA Netw Open . 2021;4:9: e2127573.

    CrossrefGoogle Scholar
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